Addiction as a coping response: hyperkatifeia, deaths of despair, and COVID-19. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. DOI: 10.1016/j.neuropharm.2017.03.006.ĭe Guglielmo G, Kallupi M, Pomrenze M, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. Addictions neuroclinical assessment: a reverse translational approach. Kwako LE, Momenan R, Grodin EN, Litten RZ, Koob GF, Goldman D. Titrating tipsy targets: the neurobiology of low-dose alcohol.
Neurobiology of addiction: a neurocircuitry analysis. Journal of Clinical Investigation 125:3193-3197. (2015) Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. Schlosburg JE, Whitfield TW Jr, Park PE, Crawford EF, George O, Vendruscolo LF, Koob G F (2013) Long-term antagonism of k-opioid receptors prevents escalation of and increased motivation for heroin intake. Koob GF, Volkow ND (2010) Neurocircuitry of addiction. (2012) Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF. Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. Development of pharmacotherapies for drug addiction: a Rosetta Stone approach. Nat Neurosci 5:625-626.įunk CK, O'Dell LE, Crawford EF, Koob GF (2006) Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. Alcoholism: Clinical and Experimental Research, 27 (2003) 232–243.Īhmed SH, Kenny PJ, Koob GF, Markou A (2002) Neurobiological evidence for hedonic allostasis associated with escalating cocaine use. Drug addiction, dysregulation of reward, and allostasis, Neuropsychopharmacology, 24 (2001) 97-129.
Drug abuse: hedonic homeostatic dysregulation, Science, 278 (1997) 52-58. Proc Natl Acad Sci USA 92:5880-5884.Īhmed SH, Koob GF (1998) Transition from moderate to excessive drug intake: change in hedonic set point. Schulteis G, Markou A, Cole M, Koob GF (1995) Decreased brain reward produced by ethanol withdrawal. Koob GF, Bloom FE (1988) Cellular and molecular mechanisms of drug dependence. Training in: physiology, behavior, neurochemistry, environmental physiology.ġ965-1969 Undergraduate, Pennsylvania State University, Training in: zoology and psychology. Studies in: brain lesions, brain stimulation, behavior, neurochemistry, psychopharmacology.ġ969-1972 Predoctoral Fellow, Johns Hopkins University, Department of Environmental Medicine. Studies in: catecholamines and behavior.ġ972-1975 Staff Scientist, Department of Neurophysiology, Walter Reed Army Institute of Research. Leslie Iversen, University of Cambridge, Department of Experimental Psychology, Medical Research Council, Neurochemical Pharmacology Unit.
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